Free fatty acids: potential proinflammatory mediators in rheumatic diseases

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Free fatty acids: potential proinflammatory mediators in rheumatic diseases.

OBJECTIVES Due to their role in inflammatory metabolic diseases, we hypothesised that free fatty acids (FFA) are also involved in inflammatory joint diseases. To test this hypothesis, we analysed the effect of FFA on synovial fibroblasts (SF), human chondrocytes and endothelial cells. We also investigated whether the toll-like receptor 4 (TLR4), which can contribute to driving arthritis, is inv...

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 2013

ISSN: 0003-4967,1468-2060

DOI: 10.1136/annrheumdis-2013-203755